Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-22
2005-02-22
Huff, Sheela J. (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C435S975000, C530S300000, C530S350000, C530S324000
Reexamination Certificate
active
06858586
ABSTRACT:
Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian cells, including cells of human origin, in vitro or in vivo. The inventive method involves the use of a composition containing a pituitary tumor transforming gene carboxy-terminal peptide (PTTG-C), which can be comprised in a chimeric protein, which has the ability to regulate endogenous pituitary tumor transforming gene (PTTG) expression and/or function in a dominant negative manner. Kits comprising the inventive compositions are also disclosed for the treatment of neoplastic cellular proliferation in vitro or in vivo. Isolated PTTG-C peptides and PTTG-C-containing chimeric proteins are described.
REFERENCES:
patent: WO 9009442 (1990-08-01), None
patent: WO 9822587 (1998-05-01), None
PCT International Search Report—PCT/US 97/21463, Nov. 22, 1997.
Marra, M., et al., “The WashC-HHMI Mouse EST project, AC W81747”, EMBL Database, Jun. 27, 1996, Heidelberg, XP002066845.
Hillier, L., et al., The WashU-Merck EST project, AC AA007646, EMBL Database, Jul. 28, 1996, Heidelberg, XP002066846.
Holton, T., et al., “ACQ57612”, EMBL Database, Sep. 5, 1994, Heidelberg, XP002066847.
Nippon Telegraph and Telephone Corp.: “ACQ75553”, EMBL Database, Aug. 4, 1995, Heidelberg, XP002066848.
Gonsky, R., et al., “Transforming DNA Sequences Present in Human Prolactin-Secreting Pituitary Tumors”, Molec. Endocrin., 5(11): 1687-1695, Nov. 1991.
Pei, L., et al., “Isolation and Characterization of a Pituitary Tumor-Transforming Gene (PTTG)”, Molec. Endocrin., 11(4): 433-441, Apr. 1997.
Shimon, I., et al., “Genetic Basis of Endocrine Disease”, J. Clin. Endocrin. And Metab., 82(6): 1675-1681, Jun. 1997.
Chen. L., et al., “Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization.”, 1: Gene May 2, 2000; 248 (102): 41-50. Abstract Only.
Heaney, A.P., “Expression of pituitary-tumor transforming gene in colorectal tumours”, 1: Lancet Feb. 26, 2000; 355(9205): 716-9.
Heaney, A.P. “Early Involvement of Estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis”, 1: Nat Med Nov., 1999; 5(11): 1317-21.
Suhardja, A.S., et al., “Molecular pathogenesis of pituitary adenomas: a review.”, Acta Neurochir (Wien) 1999; 141(7): 729-36. Abstract Only.
Ren, R., et al., “Identification of a ten-amino acid proline-rich SH3 binding site.”, Science Feb 19, 1993; 259(5098): 1157-61. Abstract Only.
Liu, X., et al., “The v-Src SH3 domain binds phosphatidylinositol 3′-kinase.”, Mol Cell Biol Sep. 1993; 13(9): 5225-32. Abstract Only.
Gout, I., et al., “The GTPase dynamin binds to and is activated by a subset of SH3 domains.” Cel Oct. 8, 1993; 75(1): 25-36.
Yu, H., et al., “Solution structure of the SH3 domain of Src and identification of its ligan-binding site.” Science Dec. 4, 1992: 258(5088): 1665-8. Abstract Only.
Lee. I.A., et al., “Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene.”, Biochem Mol. Biol Int May 1999; 47(5): 891-7. Abstract Only.
Zou, H., et al., “Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.”, Science Jul. 16, 1999; 285(5426): 418-22. Abstract Only.
Zhang, X., et al., “Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas.” J Clin Endocrinol Metab Feb. 1999; 84(2): 761-7.
Prezant, T.R., et al., “An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors; evidence for hPTTG family.”, J Clin Endocrinol Metab Mar. 1999; 84(3): 1149-52.
Fujimoto, N., et al., “Establishment of an estrogen responsive rat pituitary cell sub-line MtTE-2.” Endocr J Jun. 1999; 46(3): 389-96. Abstract Only.
Ramos-Morales, F., et al., “Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.”, Oncogene Jan. 20, 2000; 19(3): 403-9. Abstract Only.
McCabe C.J., et al., “PTTG—a new pituitary tumour transforming gene.”, J Endocrinol Aug. 1999; 162(2): 163-6. Abstract Only.
Kakar, S.S., “Molecular cloning, genomic organization. and identification of the promoter for the human pituitary tumor transforming gene (PTTG).”, Gene Nov. 29, 1999; 240(2): 317-24. Abstract Only.
Dominguez, A., et al., “hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.”, Oncogene Oct. 29, 1998; 17(17): 2187-93. Abstract Only.
Pei, L., “Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells.”, J Biol Chem Jan. 29, 1999; 274(5): 3151-8.
Saez, C., et al., “hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias.”, Oncogene Sep. 23, 1999; 18(39): 5473-6. Abstract Only.
Pei, L., “Genomic Organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene.”, J Biol Chem Feb. 27, 1998; 273(9): 5219-25.
Wang, Z., et al., “Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter.”, Endocrinology Feb. 2000; 141(2): 763-71.
Zhang, X., et al., “Structure, expression and function of human pituitary tumor-transforming gene (PTTG).”, Mol Endocrinol Jan. 1999; 13(1): 156-66.
Heaney, Anthony, P., et al., “Pituitary tumor transforming gene: a novel factor in pituitary tumour formation,” Balliere's Clinical Endocrinology and Metabolism, vol. 13, No. 3, pp. 367-380, 1999.
Deonarain; Ligand-targeted receptor-mediated vectors for gene delivery, 1998, Exp. Opin. Ther. Patents 8(1):53-69.
Eck et al.; Gene-Based Therapy, 1996, The Pharmacological Basis of Therapeutics:77-101.
Accession No. AAT21011, 1996.
Accession No. H66067, 1995.
Horwitz Gregory A.
Melmed Shlomo
Zhang Xun
Cedars-Sinai Medical Center
Huff Sheela J.
Pillsbury & Winthrop LLP
LandOfFree
Pituitary tumor transforming gene (PTTG) carboxy-terminal... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pituitary tumor transforming gene (PTTG) carboxy-terminal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pituitary tumor transforming gene (PTTG) carboxy-terminal... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3509232