Pituitary differentiaton factor and methods of use thereof

Details Pituitary differentiaton factor and methods of use thereof Pituitary differentiaton factor and methods of use thereof

1997-11-25

1999-03-30

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 695, 435 703, 435440, C12N 500, C12P 2102, C12P 2104

Patent

active

058888179

ABSTRACT:
The present invention is directed to pituitary differentiation factor (PDF), a pituitary factor that is capable of differentiating cells including breast cancer and prostatic cancer cells. Isolated nucleic acids encoding PDF and related vectors and host cells are also provided. Restoration of differentiating ability to malignantly transformed cells provides a modality of cancer therapy. The isolated and purified PDF of the invention is accordingly useful in the treatment of breast and prostatic cancer.

REFERENCES:
Bani et al. (1994) Br. J. Cancer 70: 900.
Mira-Y-Lopez et al. (1986) Proc. Nat., Acad. Sci. USA 83: 7780.
Prats et al. (1989) Proc. Natl. Acad. Sci. USA 86: 1836.
Tanigaki-Obana et al. (1994) Arch. Dermatol Res. 286: 484.
Platica et al. (1992) Endocrinology 131: 2573.
Platica et al. Endocrinology 131:2573, 1992.

Affiliated with

Also associated with

Rating

Pituitary differentiaton factor and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pituitary differentiaton factor and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pituitary differentiaton factor and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1213949