Pituitary differentiation factor and methods of use thereof

Details Pituitary differentiation factor and methods of use thereof Pituitary differentiation factor and methods of use thereof

1997-07-09

1998-08-18

Myers, Carla J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 536 2431, 4351723, 4353201, 435325, 4352523, 530530, 530399, 935 8, 935 9, 935 22, C12N 1500, C07K 14435, C07H 2104

Patent

active

057957401

ABSTRACT:
The present invention is directed to pituitary differentiation factor (PDF), a pituitary factor that is capable of differentiating cells including breast cancer and prostatic cancer cells. Isolated nucleic acids encoding PDF and related vectors and host cells are also provided. Restoration of differentiating ability to malignantly transformed cells provides a modality of cancer therapy. The isolated and purified PDF of the invention is accordingly useful in the treatment of breast and prostatic cancer.

REFERENCES:
Platica et al, Endocrinology, 1992 131(6) 2573-2580.
Bani et al. (1994) Br. J. Cancer 70:900.
Mira-Y-Lopez et al. (1986) Proc. Nat., Acad. Sci USA 83: 7780.
Prats et al. (1989) Proc. Natl. Acad. Sci. USA 86:1836.
Tanigaki-Obana et al. (1994) Arch. Dermatol Res. 286:484.

Affiliated with

Also associated with

Rating

Pituitary differentiation factor and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pituitary differentiation factor and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pituitary differentiation factor and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1113797