Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1992-09-04
1994-07-05
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 435 694, C07K 1300
Patent
active
053268601
ABSTRACT:
Disclosed are (1) a DNA containing a DNA segment coding for PACAP38; (2) a precursor protein of PACAP38; (3) a transformant containing a DNA having a DNA segment coding for PACAP38; (4) a method for preparing mature PACAP38 comprising cultivating the transformant described in the above (3), producing and accumulating a protein in a culture, and collecting the resulting protein; and (5) a method for preparing the above polypeptide comprising condensing a partial amino acid or a peptide which can constitute the mature PACAP38, with a residual portion, and removing a protective group if a product has the protective group. The DNA is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. PACAP38 provides information about growth and maintenance of rat and human brain nerves, and can also be utilized as therapeutic agents for various neuropathy.
REFERENCES:
patent: 5128242 (1992-07-01), Arimura et al.
Tatsuo, et al., Endocrinology 129(4): 1797-1804 (1991).
Miyata, et al. 71st Annual Meeting of The Endocrine Society, Seattle, Wash., Jun. 21-24, 1988, Abstract #168.
Arimura, et al., 71st Annual Meeting of the Endocrine Society, Seattle, Wash., Jun. 21-24, 1989 Abstract #964.
Kimura, et al., Biochem. & Biophys. Res. Comm. 166(1) 81-90 (1990).
Arimura Akira
Kimura Chiharu
Kitada Chieko
Onda Haruo
Cermak Shelly Guest
Conlin David G.
Eisenstein Ronald I.
Hill Jr. Robert J.
Takeda Chemical Industries Ltd.
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