Chemistry: analytical and immunological testing – Metal or metal containing – Present in biological fluids
Patent
1997-11-26
2000-12-26
Snay, Jeffrey
Chemistry: analytical and immunological testing
Metal or metal containing
Present in biological fluids
436 79, 436164, 436172, 422 57, 422 8206, 422 8207, G01N 2180
Patent
active
061657964
ABSTRACT:
A pipettable detector comprises an aqueous suspension of particles which are essentially insoluble in a sample of a body fluid containing at least one target ion analyte of interest, the particles having uniformly distributed therein target and indicator ionophores which may be present in the same molecule or separate molecules. The indicator ionophore is capable of giving rise to a detectable signal following complexation of the target ionophore with the target ion from the sample. In a method of detecting an ionic analyte of interest in the sample of a bodily fluid, the sample is contacted with the detector. The indicator ionophore gives rise to a detectable signal following complexation of the target ionophore with the target ion from the sample, and the signal is then detected.
REFERENCES:
patent: 3862302 (1975-01-01), Price et al.
patent: 3873683 (1975-03-01), Fishbein
patent: 3955928 (1976-05-01), Yee
patent: 3991175 (1976-11-01), Grundman
patent: 4016250 (1977-04-01), Saxena
patent: 4033723 (1977-07-01), Givner et al.
patent: 4071314 (1978-01-01), Prugnaud
patent: 4123509 (1978-10-01), Banik et al.
patent: 4348019 (1982-09-01), Cappel
patent: 4382122 (1983-05-01), Mezel et al.
patent: 4433057 (1984-02-01), de Gracia
patent: 4508829 (1985-04-01), Sulitzeanu
patent: 4762799 (1988-08-01), Seitz et al.
patent: 4943522 (1990-07-01), Eisinger et al.
patent: 4985204 (1991-01-01), Klose et al.
patent: 5128019 (1992-07-01), Karpf et al.
patent: 5133934 (1992-07-01), Denton et al.
patent: 5145789 (1992-09-01), Corti et al.
patent: 5185270 (1993-02-01), Senyei et al.
patent: 5215924 (1993-06-01), Rittersdorf et al.
patent: 5217875 (1993-06-01), Karpf et al.
patent: 5266486 (1993-11-01), Fraatz et al.
patent: 5372936 (1994-12-01), Fraatz et al.
patent: 5405975 (1995-04-01), Kuhn et al.
patent: 5573909 (1996-11-01), Singer et al.
patent: 5648270 (1997-07-01), Kuhn et al.
Seiler, K., et al: Characterization of Sodium-Selective Optode Membranes Based on Neutral Ionophores and Assay of Sodium in Plasma; Clinical Chemistry, vol. 37, No. 8; Aug. 1, 1991, pp. 1350-1355.
Dalgleish, Douglas G., et al; Ionic Strength Effects on the Electrophoretic Mobility of Casein-Coated Polystyrene Latex Particles; Journal of Colloid and Interface Science, vol. 108, No. 1, 1985, pp. 174-179.
Bakker E., et al; Ion-Selective Electrodes Based on Two Competitive Ionophores for Determining Effective Stability Constants of Ion-Carrier Complexes in Solvent Polymeric Membranes; Analytical Chemistry, vol. 70, No. 2, Jan. 15, 1998.
Nakamura, H., et al; Chromogenic Crown Ether Reagents for Spectrophotometric Determinations of Sodium and Potassium; Analytica Chimica Acta, 139 (1982), pp. 219-227.
Vaidya, Bikas, et al; Chromogenic and Fluorogenic Crown Ether Compounds for the Selective Extraction and Determination of Hg(II); Anal. Chem. 1995, 67, pp. 4101-4111.
Uniform Latex Particles; pp. 41-42; published by Bangs Laboratories, Inc. of Carmel, Indiana.
Beckman Coulter Inc.
Kivinski Margaret A.
May William H.
Snay Jeffrey
LandOfFree
Pipettable ion detector and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pipettable ion detector and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pipettable ion detector and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-993660