Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-12-18
1994-09-27
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514317, 514326, 514327, 546214, 546216, 546219, 546242, 546248, C07D21196, A61K 31445
Patent
active
053507584
ABSTRACT:
The present invention relates to piperidyl sulfonamides and sulfoxamides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
REFERENCES:
patent: 2580411 (1952-01-01), Cusic
patent: 3178439 (1965-04-01), Cislak
patent: 3185678 (1966-05-01), Abood
patent: 4316903 (1982-02-01), Grier et al.
patent: 4326067 (1982-04-01), Fazio
patent: 4565819 (1986-01-01), Vincent et al.
patent: 4695575 (1987-09-01), Janssens et al.
patent: 4812451 (1989-03-01), Shanklin, Jr. et al.
patent: 4857648 (1989-08-01), Broger et al.
patent: 4906659 (1990-03-01), Harada et al.
patent: 4940705 (1990-07-01), Boshagen et al.
patent: 5084461 (1992-01-01), Wannamaker et al.
Ikeda et al., Heterocycles, 27(4), pp. 943-953 (1988).
Mercer, et al., Comp. Biochem. Physiol 80B(2):341-346 (1985).
Jeney, et al., Chemical Abstract 67(5):21035p (1967).
Beger, et al., Chemical Abstract 89(23):196901z (1978).
Mathison, et al., Chemical Abstracts 78(11):71860b (1973).
Matsuda, et al., Chemical Abstracts 109(7):50259f (1988).
Kameoka, et al., Chemical Abstracts 104(6)43107y (1986).
Chemical Abstracts 51(17):12907 (1957).
Barney, et al., Tetrahedron Letters 31(39):5547-5550 (1990).
Zeyyreu, et al., Chapter 6 "Kinetics III-Reversible Inhibition of Enzyme action" in The Study of Enzyme Mechanisms, A Wiley-Interscience Publication (1974).
Pike and Brown, "Nutrition:An Integrated Approach" J. Wiley & Sons, pp. 531-535 (1954).
Ferles, et al., Chemical Abstracts 79(23):136948d (1973).
Gerst, et al., Biochemical Pharmacology 37(10):1955-1964 (1988).
Moore William R.
VanSickle William A.
Wannamaker Marion W.
Barney Charlotte L.
Cintins Marianne M.
Merrell Dow Pharmaceuticals Inc.
Spivack Phyllis G.
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