(Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S326000, C546S189000, C546S193000, C546S208000, C546S209000, C546S210000

Reexamination Certificate

active

07608629

ABSTRACT:
The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HT1Freceptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.

REFERENCES:
patent: 4110459 (1978-08-01), Helsley et al.
patent: 5118689 (1992-06-01), Oinuma et al.
patent: 5254689 (1993-10-01), Butera et al.
patent: 5286866 (1994-02-01), Carr et al.
patent: 5521196 (1996-05-01), Audia et al.
patent: 5521197 (1996-05-01), Audia
patent: 5708008 (1998-01-01), Audia et al.
patent: 5708187 (1998-01-01), Flaugh et al.
patent: 5721252 (1998-02-01), Audia et al.
patent: 5814653 (1998-09-01), Flaugh et al.
patent: 5942536 (1999-08-01), Fritz et al.
patent: 5962474 (1999-10-01), Audia et al.
patent: 5965562 (1999-10-01), Ofner et al.
patent: 6001849 (1999-12-01), Elliott et al.
patent: 6133290 (2000-10-01), Krushinski et al.
patent: 6358972 (2002-03-01), Filla et al.
patent: 6878714 (2005-04-01), Askew et al.
patent: 7105682 (2006-09-01), Chen et al.
patent: 705851 (1996-04-01), None
patent: A-33174/95 (1996-04-01), None
patent: 0 733 628 (1996-09-01), None
patent: 0 832 650 (1998-04-01), None
patent: 0 832 650 (1998-04-01), None
patent: WO 95 00131 (1995-01-01), None
patent: WO 96 29075 (1996-09-01), None
patent: WO-97/08144 (1997-03-01), None
patent: WO 97 13512 (1997-04-01), None
patent: WO 97/08144 (1997-06-01), None
patent: WO 98 08502 (1998-03-01), None
patent: WO 98 15545 (1998-04-01), None
patent: WO 98 20875 (1998-05-01), None
patent: WO 98 46570 (1998-10-01), None
patent: WO 98 55115 (1998-12-01), None
patent: WO 99 25348 (1999-05-01), None
patent: WO 00 00490 (2000-01-01), None
patent: WO 00 34266 (2000-06-01), None
patent: WO 00 47559 (2000-08-01), None
patent: WO 00 50426 (2000-08-01), None
patent: WO 00/00487 (2000-10-01), None
patent: WO 03/084949 (2003-10-01), None
patent: WO 2004/094380 (2004-04-01), None
Phebus et al. “Characterization of LY344864 . . . ” CA 128:18603 (1997).
Pruecher et al. “Preparation of 3-aryl . . . ” CA 122:265361 (1995).
Gaster et al. “Preparation of arylacetamide . . . ” CA 130:13850 (1998).
Cohen et al. “5-hydroxytryptamine1F . . . ” CA 131:266942 (1999).
Chen et al. “Preparation fo substituted2-(1H-indazol . . . ”CA 137:216945 (2002).
Eriksson et al. “Preparation of 5-substituted imidazolidine . . . ” CA 137:247696 (2002).
Askew et al. “Preparation of 2-aminopyridine . . . ” CA 140:16647 (2003).
King “Bioisosteres, conformational . . . ” Med. Chem. Principle and Practice. p. 206-208 (1994).
Wainscott et al. “Human 5-HT1F receptor stimulated . . . ” European J. Pharm. 352 p. 117-124 (1998).
Blanco et al. “Preparation of N-piperidinyloxy . . . ” CA 141:395422 (2004); and sample structure delineation.
Blanco et al. “Novel stubstituted N-3-1-methyl-piperidinyl . . . ” CASPLUS AN 2004:226622 (2004).
Migraine National headache foundation (2009) (one page from internet).
MayoClinic “migraine” (2009) (twelve pages from internet).
Widipedia “headache” (2009) (six pages from internet).
Parsons et al. “the neuronal verss vascular hypothesis of migraine . . . ” Curr. Opin. Pharm. v.3, p. 73-77 (2003).
Adham N et al: “Cloning of Another Human Serotonin Receptor (5-HT1F): A Fifth 5-HT1Receptor Subtype Coupled to the Inhibition of Adenylate Cyclase” Proceedings of the National Academy of Sciences of USA,US. National Academy of Science. Washington, vol. 9, No. 2, 408-412, (1993).
Johnson K, “5-HT1Freceptor agonists inhibit neurogenic dural inflammation in guinea pigs”NeuroReport8, 2237-2240 (1997).
Streitwiser, et al, “Introduction to Organic Chemistry” MacMillian Publishing Co. Inc., 586-587 (1976).
Graham, et al, “Mechanism of Migraine Headache and Action of Ergotamine Tartrate”Archives of Neurol. Psychiatry, 39:737-63, (1938).
Humphrey, et al., “Serotonin and Migraine”Ann. NY Acad. Sci., 600:587-600, (1900).
Moskowitz, M, “Interpreting vessel diameter changes in vascular headaches” Cephalalgia, 12:5-7, (1992).
Moskowitz, A. “Neurogenic inflammation in the pathophysiology and treatment of migraine”Neurology, 43 (suppl. 3) :S16-S20 (1993).
Johnson, K, et al. “A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation”.Neurosciences Methods81, 19-24 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

(Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4097516

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.