Piperidinyl prostaglandin E analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S315000, C514S318000, C514S319000, C514S322000, C514S324000, C514S327000, C546S024000, C546S192000, C546S193000, C546S196000, C546S202000, C546S205000, C546S210000, C546S212000, C546S213000, C546S214000, C546S216000, C546S242000, C546S243000

Reexamination Certificate

active

06977260

ABSTRACT:
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I;wherein X, Y, Z, D and R3are as defined in the specification.

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patent: WO2004/063158 (1929-04-01), None
patent: WO2004/085430 (2004-07-01), None
Bito, L.Z.,Biological Protection with Prostaglandins, Cohen, M.M., ed., Boca Raton, Fla, CRC Press Inc., 1985, pp. 231-252.
Bito, L.Z.,Applied Pharmacology in the Medical Treatment of Glaucomas, Drance, S.M. and Neufeld, A.H. eds, New York, Grune & Stratton, 1984, pp. 477-505.
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Bito, L.Z.,Arch. Ophthalmol.105, 1036 (1987).
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Huang et al, Synth. Commun., “Preparation of Optically Pure ω-Hydroxymethyl Lactams”, 1989, 19, 3485-3496.

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