Piperidinyl derivatives as modulators of chemokine receptor...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S330000

Reexamination Certificate

active

07985861

ABSTRACT:
The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.

REFERENCES:
patent: 5492920 (1996-02-01), Chen et al.
patent: 5847148 (1998-12-01), Jacobsen et al.
patent: 6194448 (2001-02-01), Biediger et al.
patent: 6344449 (2002-02-01), Rudolf et al.
patent: 6391865 (2002-05-01), Baroudy et al.
patent: 6638950 (2003-10-01), Duncia et al.
patent: 6794507 (2004-09-01), Cappi et al.
patent: 6846836 (2005-01-01), Hamann et al.
patent: 7601844 (2009-10-01), Carter et al.
patent: 2003/0162764 (2003-08-01), Castelhano et al.
patent: 2003/0229067 (2003-12-01), Castelhano et al.
patent: 2004/0006067 (2004-01-01), Fotsch et al.
patent: 2005/0227968 (2005-10-01), Lustenberger et al.
patent: 2005/0250814 (2005-11-01), Zhou et al.
patent: 2007/0123509 (2007-05-01), Cezanne et al.
patent: 2007/0179148 (2007-08-01), Carter et al.
patent: 2010/0204274 (2010-08-01), Gardner et al.
patent: 4243858 (1994-06-01), None
patent: 0838460 (1998-04-01), None
patent: 2001/354657 (2000-12-01), None
patent: WO 92/15304 (1992-09-01), None
patent: WO 94/25437 (1994-11-01), None
patent: WO 95/34311 (1995-12-01), None
patent: WO 97/38665 (1997-10-01), None
patent: WO 98/17625 (1998-04-01), None
patent: WO 99/08697 (1999-02-01), None
patent: WO 99/08699 (1999-02-01), None
patent: WO 00/74679 (2000-12-01), None
patent: WO 02/059117 (2002-08-01), None
patent: WO 02/070511 (2002-09-01), None
patent: WO 02/092582 (2002-11-01), None
patent: WO 03/007949 (2003-01-01), None
patent: WO 03/009847 (2003-02-01), None
patent: WO 03/022835 (2003-03-01), None
patent: WO 03/092688 (2003-11-01), None
patent: WO 2004/037796 (2004-05-01), None
patent: WO 2004/076418 (2004-09-01), None
patent: WO 2004/113323 (2004-12-01), None
patent: WO 2005/003127 (2005-01-01), None
patent: WO 2005/056015 (2005-06-01), None
patent: WO 2005/084672 (2005-09-01), None
patent: WO 2005/118579 (2005-12-01), None
patent: WO 2006/013073 (2006-02-01), None
Baraldi, P. et al., “Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7receptor”, J. Med. Chem., vol. 46, pp. 1318-1320 (2003).
Carson, K. et al., “CCR1 Antagonists”, Annual Reports in Medicinal Chemistry, vol. 39, pp. 149-158 (2004).
Lang, L. et al., (Database Beilstein, Beilstein Institute for Organic Chemistry, BRN#: 8854794), J. Labelled Compd. Radiopharm., vol. 44, pp. S21-S23 (2001).
Oshiro, Y. et al., “Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives”, J. Med. Chem., vol. 34, No. 7, pp. 2014-2023 (1991).
Pessoa-Mahana, H. et al., “Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action”, Synthetic Communications, vol. 34, No. 14, pp. 2513-2521 (2004).
Richardson, T. et al., “Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor”, J. Med. Chem., vol. 47, pp. 744-755 (2004).
Tiwari, M., (Database Beilstein, Beilstein Institute for Organic Chemistry, BRN#: 943608, 944316), J. Indian Chem. Soc., vol. 53, pp. 310-311 (1976).
F.Z. Dorwald “Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design” 2005, Wiley-VCH Verlag GMBH & Co. KGaA, Wienheim.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Piperidinyl derivatives as modulators of chemokine receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidinyl derivatives as modulators of chemokine receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidinyl derivatives as modulators of chemokine receptor... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2635329

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.