Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-02-27
2007-02-27
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S238000
Reexamination Certificate
active
10508676
ABSTRACT:
The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety
REFERENCES:
patent: WO-03/010166 (2003-02-01), None
Borsini et al. (2002) Do animals models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology 163:121-141.
Weems et al. Clinical Child and Family Psychology Review, vol. 8, No. 2, Jun. 2005 (pp. 107-134).
Abstract from Rynn et al. J. Clin Psychiatry, 2002; 63 Suppl 14: 9-16 (one page).
Corsano, S. et al., “New 3(2H)-Pyridazinone Derivatives: Synthesis and Affinity Towards Alpha(1)AR Substypes and 5HT(1A) Receptors”, European Journal of Medicinal Chemistry Editions Scientifique Elsevier, Paris, France. vol. 32, No. 4, 1997, pp. 339-342.
Barkóczy József
Gacsályi István
Hársing László Gábor
Kótay Nagy Péter
Lévay György
Birch Stewart Kolach & Birch LLP
Egis Gyogyszergyar RT.
Habte Kahsay
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