Piperidinesulfonylurea derivatives

Details Piperidinesulfonylurea derivatives Piperidinesulfonylurea derivatives

1976-09-24

1977-10-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31505

Patent

active

040525074

ABSTRACT:
A series of novel 1-piperidinesulfonylurea compounds derived from a pyrimidine monocarboxylic acid have been prepared by reacting an appropriate sulfamide with an organic isocyanate or a trisubstituted urea equivalent thereof. The sulfamylureas so obtained are useful in therapy as oral hypoglycemic agents. Typical members include those compounds derived from 1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione-5-carboxylic acid, of which 1-(bicyclo[2.2.1]hept-5-en-2-yl-endo-methyl)-3-{4-[2-(1,3-dimethyl-1,2,3,4 -tetrahydropyrimidine-2,4-dione-5-carboxamido)ethyl]-1-piperidinesulfonyl}u rea is a most preferred embodiment.

REFERENCES:
patent: 3705899 (1972-12-01), Regniev et al.

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