Piperidines, processes of preparation and medications containing

Details Piperidines, processes of preparation and medications containing Piperidines, processes of preparation and medications containing

1990-01-05

1991-03-19

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514316, 514326, 514330, 546187, 546189, 546198, 546225, 546207, C07D41304, C07D21132, A61K 31445, A61K 3142

Patent

active

050011340

ABSTRACT:
The present invention relates to piperidines denoted by the formula: ##STR1## in which X is the 4-fluorobenzoyl, 2-(4-fluorophenyl)-1,3-dioxolan-2-yl or 6-fluoro-1,2-benzisoxazol-3-yl group, Y is a hydrogen atom or the hydroxyl group, m is an integer between 0 and 4 inclusive, n is 0 or 1, Q is a nitrogen atom or the methine group; when Q is a nitrogen atom, R is the cyano group or the carbamoyl group; when Q is the methine group, R is the nitro group; R.sup.1 and R.sup.2 may be identical or different and are hydrogen, a lower alkyl radical, the phenyl radical, the 2,2,2-trifluoroethyl group or the 2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl group; or the NR.sup.1 R.sup.2 structural unit is the piperidino radical or the 4-(4-fluorobenzoyl)-1-piperidinyl group.
Application of these compounds as antihypertensive medications.

REFERENCES:
patent: 4355037 (1982-10-01), Strupczewski et al.

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