Piperidines and related compounds for treatment of...

Details Piperidines and related compounds for treatment of... Piperidines and related compounds for treatment of...

2005-10-20

2009-12-29

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S192000, C514S304000, C514S317000

Reexamination Certificate

active

07638629

ABSTRACT:
Compounds of formula I:selectively inhibit production of Aβ(1-42) and hence are useful in treatment or prevention of disease associated with deposition of β-amyloid in the brain.

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Int. Rev. Psy., Dec. 2007, 19, 693-706.
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F. Bustos et al., “Synthesis of 2,4-, 3,4-, 2,3,4-substituted pyrrolidines by cyclization of neutral C-centered alpha-aminoalkyl redicals”, Tetrahedron, vol. 58, pp. 6837-6842 (2002).
K. Achiwa et al., “1,3-Dipolar Cycloaddition Leading To N-Alkylpyrrolidines”, Chemical and Pharmaceutical Bulletin, vol. 32, pp. 2878-2881 (1984).
International Preliminary Report on Patentability for PCT/GB2005/004040 (Apr. 24, 2007).

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