Piperidine opioid antagonists

Details Piperidine opioid antagonists Piperidine opioid antagonists

1988-12-14

1990-01-02

Freidman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

048913790

ABSTRACT:
This invention provides trans-3,4 1-substituted-3-substituted-4-methyl-4-(3-substituted phenyl)piperidines as opioid antagonists capable of blocking the mu or kappa receptors in the brain.

REFERENCES:
patent: 3991199 (1976-11-01), Berger
patent: 4141980 (1979-02-01), Berger
patent: 4191771 (1980-03-01), Zimmerman
patent: 4581456 (1986-04-01), Barnett
Leander et al., European Journal of Pharmacology 81, 185-192.
Leander et al., Drug Development Research 4:421-427 (1984).
Baile et al., Physiology & Behavior, vol. 26, 1019-1023 (1981).
Zimmerman et al., Nature, vol. 275, Sep. 28, 1978, pp. 332-334.
Leander, The Journal of Pharmacology and Experimental Therapeutics, vol. 224, N-. 1, 89-94 (1983).

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