Piperidine derivatives useful as modulators of chemokine...

Details Piperidine derivatives useful as modulators of chemokine... Piperidine derivatives useful as modulators of chemokine...

2007-09-04

2007-09-04

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S242000

Reexamination Certificate

active

10483138

ABSTRACT:
The invention provides compounds of formula (I) wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR11or N; n is 0, 1 or 2; m is 1 or, when Y is CR11m is 0; R1is optionally substituted aryl or optionally substituted heterocyclyl; R2, R3, R,4, R5, R6, R7and R8are, independently, hydrogen or C?1-6#191 alkyl; R9is hydrogen or C1-C6alkyl; R10is alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; and R11is hydrogen or C1-C6allkyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

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