Piperidine derivatives useful as CCR5 antagonists

Details Piperidine derivatives useful as CCR5 antagonists Piperidine derivatives useful as CCR5 antagonists

2008-04-17

2011-10-11

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

08034933

ABSTRACT:
The present invention provides a compound of the formulaor a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R9, R10, A and B are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

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Anandan Palani et al., “Discovery of 4-[(Z)-(4-Bromophenyl)-(ethoxyimino)methyl]-1′-[(2,4—dimethyl-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection”, Journal of Medicinal Chemistry, vol. 44, No. 21, Oct. 11, 2001, pp. 3339-3342.
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