Piperidine derivatives, their preparation and their therapeutic

Details Piperidine derivatives, their preparation and their therapeutic Piperidine derivatives, their preparation and their therapeutic

1992-04-02

1994-01-18

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514321, 546193, 546198, 546199, C07D40114, A61K 31445

Patent

active

052800300

ABSTRACT:
A compound which is a piperidine derivative of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom, a linear or branched (C.sub.1-6)alkyl group or a cyclo(C.sub.3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formula N--R.sub.3 in which R.sub.3 is a hydrogen atom, or a linear or branched (C.sub.1-8)alkyl, cyclo(C.sub.3-6)alkyl, cyclo(C.sub.3-6)alkylmethyl, (C.sub.1-4)alkoxy-(C.sub.1-4)alkyl, phenyl, pyridin-4-yl, pyridin-3-yl, pyridin-4-ylmethyl or pyridin-3-ylmethyl group and Z represents a hydrogen or fluorine atom and acid addition salts thereof with pharmaceutically acceptable acids, can be used for the treatment and prevention of disorders in which 5-HT receptors are involved.

REFERENCES:
patent: 4634704 (1987-01-01), Jausseus
patent: 4879301 (1989-11-01), Umico
Tyers et al "5-HT.sub.3 Receptors" N.Y. Academy Sci. 600 pp. 194-199, 215-216 (1990).
Foks et al "Pyraziue Derivatives" CA 90:168536m (1979).
Barchas et al "Serotonin and Behavior" Academic Press, pp. 235-238 (1973).
Glennon "Central Serotonin Receptors . . . " J. Med. Chem. 30(1) 1-12 (1986).

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