Piperidine derivatives as neurokinin antagonists

Details Piperidine derivatives as neurokinin antagonists Piperidine derivatives as neurokinin antagonists

1995-06-06

1997-08-05

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514327, 514329, 514331, 5142278, 5142325, 544 62, 544128, A61K 3147, C07D40112

Patent

active

056543166

ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein X, i, j, n, n', A, A', R.sub.2, R.sub.3, and U are as described herein. The compounds of the invention are NK.sub.1 or NK.sub.2 or NK.sub.3 receptor antagonists and as such are useful in the treatment of diseases such as asthma.

REFERENCES:
patent: 5350852 (1994-09-01), Emonds-Alt et al.
patent: 5387595 (1995-02-01), Mills
patent: 5411971 (1995-05-01), Emonds-Alt
patent: 5434158 (1995-07-01), Shah

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