Piperidine derivatives as CCR5 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S186000, C546S188000

Reexamination Certificate

active

10529776

ABSTRACT:
Disclosed are compounds of formula I:wherein R1, R2, R3and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.

REFERENCES:
patent: 2004/0142920 (2004-07-01), Albert et al.
patent: WO9801425 (1998-01-01), None
patent: 00/66559 (2000-11-01), None
patent: WO0066559 (2000-11-01), None
patent: 02/081449 (2002-10-01), None
patent: WO02081449 (2002-10-01), None
patent: 03/020716 (2003-03-01), None
: http://www.bakerbotts.com/infocenter/publications/detail.aspx?id=bffe4a7d-5beb-4cf8-a189-15a5f190f0eb).
http://www.dorsey.com/publications/legal—detail.aspx?FlashNavID=pubs—legal&pubid=170565003).
Cohen et al., Am. J. Clin. Pathol., 1996, 105, 589.
Assigment WO 02/081449, U.S. Appl. No. 10/472,653.
Thom et al. “Orally bioavailable . . . ” J. Med. Chem. 47, p. 1939-55 (2004).
Jewell et al. “Susceptibility . . . ” CA 134:250801 (2001).
Youhua et al. “Clinical study of . . . ” Transplatation Proceedings v.32 p. 1704 (2000).
Palani et al., “Discovery of 4-[(Z)-(4-Bromophenyl)-(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the treatment of HIV Infection”, J. Med. Chem., vol. 44, No. 21, pp. 3339-3342 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Piperidine derivatives as CCR5 inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine derivatives as CCR5 inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine derivatives as CCR5 inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3953337

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.