Piperidine derivatives

Details Piperidine derivatives Piperidine derivatives

1978-01-03

1981-02-03

MIlestone, Norma S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546216, 546222, 546207, 546219, C07D21142, A61K 31445

Patent

active

042488761

ABSTRACT:
The invention concerns novel piperidine derivatives of the formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 represents (lower)alkyl, R.sup.2 represents a phenyl group optionally substituted by one or more (lower)alkyl, (lower)alkoxy, halogen, amino, (lower)alkylamino, di(lower)alkylamino or trifluoromethyl substituents and X represents=O; ##STR2## [where R.sup.3 and R.sup.4 both represent hydrogen, both represent the same (lower)alkyl or one is hydrogen and the other is (lower)alkyl or R.sup.3 and R.sup.4 together represent an alkylene group such that the ##STR3## is a cyclic ketal group containing 2 or 3 carbon atoms]; or ##STR4## [where OR is hydroxy, etherified hydroxy or esterified hydroxy]. The compounds possess anti-depressant activity.

REFERENCES:
patent: 2997478 (1961-08-01), Walter et al.
patent: 3094463 (1963-06-01), Biel
patent: 3853892 (1974-12-01), Rossi
patent: 4072685 (1978-02-01), Nedelec et al.
G. Lambrecht, Arch. Pharm. (1975), vol. 308(6), pp. 459-464.
Chemical Abstracts, vol. 60, 7332f.
R. E. Bowman et al., J.C.S. Perkin I, 1972, pp. 2878-2882.
N. Dennis et al., J.C.S. Perkin I, 1976, pp. 2329-2334.
E. A. Mistryukov et al., Izv. Akad. Nauk SSSR, Ser. Khim. (1969), (12) pp. 2800-2804.
P. T. Lansbury et al., J. Amer. Chem. Soc., 1968, 90, pp. 536-537.
F. E. Ziegler et al., J. Amer. Chem. Soc., 1973, 95, pp. 7458-7464.

Affiliated with

Also associated with

Rating

Piperidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-550997