Piperidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S249000, C544S091000, C544S092000, C544S279000, C544S349000

Reexamination Certificate

active

10502255

ABSTRACT:
The present invention relates to piperidine derivatives of formula (I):R represents halogen or C1-4alkylR1represents C1-4alkyl;R2or R3independently represent hydrogen or C1-4alkyl;R4represents trifluoromethyl, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or halogen;R5represents hydrogen, C1-4alkyl or C3-7cycloalkyl;R6is hydrogen and R7is a radical of formula (W): or R6is a radical of formula (W) and R7is hydrogen;X represents CH2, NR5or O;Y represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen;A represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH, A is not S(O)q;m is zero or an integer from 1 to 3;n is an integer from 1 to 3;p and q are independently an integer from 1 to 2;and pharmaceutically acceptable salts and solvates thereof.The process for their preparation and their use in the treatment of a condition mediated by tachykinins.

REFERENCES:
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4110327 (1978-08-01), Saikawa et al.
patent: 4112090 (1978-09-01), Saikawa et al.
patent: 4219554 (1980-08-01), Saikawa et al.
patent: 4308387 (1981-12-01), Bjork et al.
patent: 4327097 (1982-04-01), Saikawa et al.
patent: 4379152 (1983-04-01), Saikawa et al.
patent: 4410522 (1983-10-01), Saikawa et al.
patent: 5028610 (1991-07-01), Hirai et al.
patent: 5109014 (1992-04-01), Jacobson et al.
patent: 5334606 (1994-08-01), MacLeod et al.
patent: 5348955 (1994-09-01), Greenlee et al.
patent: 5360820 (1994-11-01), Hagan et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5538982 (1996-07-01), Hagan et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5576317 (1996-11-01), Gonsalves et al.
patent: 5696123 (1997-12-01), Dollinger et al.
patent: 5698538 (1997-12-01), Amparo et al.
patent: 5708006 (1998-01-01), Dollinger et al.
patent: 5710169 (1998-01-01), Russell et al.
patent: 5716942 (1998-02-01), Dorn et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5814636 (1998-09-01), Katano et al.
patent: 5859015 (1999-01-01), Graham et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5935951 (1999-08-01), Ofner et al.
patent: 5952315 (1999-09-01), Baker et al.
patent: 5977104 (1999-11-01), Baker et al.
patent: 5985881 (1999-11-01), Dollinger et al.
patent: 5998444 (1999-12-01), Russell et al.
patent: 6037352 (2000-03-01), Lowe et al.
patent: 6057323 (2000-05-01), Zhang et al.
patent: 6090807 (2000-07-01), Hellendahl et al.
patent: 6114315 (2000-09-01), Baker et al.
patent: 6117855 (2000-09-01), Carlson et al.
patent: 6147083 (2000-11-01), Russell et al.
patent: 6191135 (2001-02-01), Dollinger et al.
patent: 6191139 (2001-02-01), Hagan et al.
patent: 6197772 (2001-03-01), Janssens et al.
patent: 6235732 (2001-05-01), Dollinger et al.
patent: 6288068 (2001-09-01), Lowe et al.
patent: 6319953 (2001-11-01), Carlson et al.
patent: RE37886 (2002-10-01), Janssens et al.
patent: 6521621 (2003-02-01), Janssens et al.
patent: 6642240 (2003-11-01), Alvaro et al.
patent: 2002/0103205 (2002-08-01), Lowe et al.
patent: 2519400 (1978-04-01), None
patent: 287734 (1987-10-01), None
patent: 293532 (1987-10-01), None
patent: 0532456 (1993-03-01), None
patent: 0655442 (1995-05-01), None
patent: 718287 (1995-12-01), None
patent: 0721941 (1996-07-01), None
patent: 1-326 632 (2003-07-01), None
patent: 1508062 (1975-04-01), None
patent: 57/118587 (1982-07-01), None
patent: WO 92/16111 (1992-10-01), None
patent: WO 95/00498 (1995-01-01), None
patent: WO 95/25443 (1995-09-01), None
patent: WO 96/02503 (1996-02-01), None
patent: WO 96/03378 (1996-02-01), None
patent: WO 96/10562 (1996-04-01), None
patent: WO 96/14844 (1996-05-01), None
patent: WO 96/20173 (1996-07-01), None
patent: WO 97/16440 (1997-05-01), None
patent: WO 97/24324 (1997-07-01), None
patent: WO 97/32865 (1997-09-01), None
patent: WO 97/36592 (1997-10-01), None
patent: WO 97/36593 (1997-10-01), None
patent: WO 97/36888 (1997-10-01), None
patent: WO 97/36889 (1997-10-01), None
patent: WO 98/01133 (1998-01-01), None
patent: WO 98/20001 (1998-05-01), None
patent: WO 98/57954 (1998-12-01), None
patent: WO 99/09985 (1999-03-01), None
patent: WO 99/26921 (1999-06-01), None
patent: WO 99/37304 (1999-07-01), None
patent: WO 01/25219 (2001-04-01), None
patent: WO 02/00631 (2002-01-01), None
patent: WO 02/32867 (2002-04-01), None
patent: WO 02/032867 (2002-04-01), None
patent: WO 02/055518 (2002-07-01), None
patent: WO 02/057233 (2002-07-01), None
patent: WO 04/033428 (2004-04-01), None
patent: WO-04 091624 (2004-10-01), None
Challet, E., et al. Neuropharmacology 40(3):408-415 (2001).
Davis, David T., “Synthesis A. Biological Activity of a Series of Piperazin-2, 3-Biones,” Journal of Antibiotics, vol. XLII, No. 3, 1989, pp. 367-373.
Megens, A., et al. J. Pharmacology and Experimental Therapeutics 302(2):696-709 (2002).
Pacher, P., et al. “Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants.” Current Medicinal Chemistry, 5, pp. 381-390, 1998.
Romerio, et al. Clinical Pharmacology and Therapeutics 66(5):522-527 (1999).
Rupniak et al. “Differential inhibition of foot tapping and chromodacyorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK, receptor antagonists.” European Journal of Pharmacology 265:179-183 (1994).
Giardina G.A.M., et al; Recent advances in neurokinin-3 receptor antagonists.: Expert Opinion On-Therapeutic Patients; 2000. 10(6); 939-960; Ashley Publications; GB.
Acute Stress Disorder; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; pp. 469-472; American Psychiatric Association; Washington, DC, USA.
Anxiety Disorders; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; 429-30; American Psychiatric Association; Washington, DC, USA.
Argyropoulos, et al.; Exp. Opin. Invest. Drugs; 2000; 9/6; 1871-1876.
Ballard, et al.; European Journal of Pharmacology; 2001; 412; 266-284.
Kramer et al.; Science; 1998; 281; 1640-1646.
Scrima, et al.; Biol Psychiatry; 1989; 26; 331-343.
Sleep disorders; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; 597-661; American Psychiatric Association; Washington, DC, USA.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Piperidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3783202

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.