Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-13
2007-03-13
Tucker, Zachary C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S249000, C544S091000, C544S092000, C544S279000, C544S349000
Reexamination Certificate
active
10502255
ABSTRACT:
The present invention relates to piperidine derivatives of formula (I):R represents halogen or C1-4alkylR1represents C1-4alkyl;R2or R3independently represent hydrogen or C1-4alkyl;R4represents trifluoromethyl, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or halogen;R5represents hydrogen, C1-4alkyl or C3-7cycloalkyl;R6is hydrogen and R7is a radical of formula (W): or R6is a radical of formula (W) and R7is hydrogen;X represents CH2, NR5or O;Y represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen;A represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH, A is not S(O)q;m is zero or an integer from 1 to 3;n is an integer from 1 to 3;p and q are independently an integer from 1 to 2;and pharmaceutically acceptable salts and solvates thereof.The process for their preparation and their use in the treatment of a condition mediated by tachykinins.
REFERENCES:
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4110327 (1978-08-01), Saikawa et al.
patent: 4112090 (1978-09-01), Saikawa et al.
patent: 4219554 (1980-08-01), Saikawa et al.
patent: 4308387 (1981-12-01), Bjork et al.
patent: 4327097 (1982-04-01), Saikawa et al.
patent: 4379152 (1983-04-01), Saikawa et al.
patent: 4410522 (1983-10-01), Saikawa et al.
patent: 5028610 (1991-07-01), Hirai et al.
patent: 5109014 (1992-04-01), Jacobson et al.
patent: 5334606 (1994-08-01), MacLeod et al.
patent: 5348955 (1994-09-01), Greenlee et al.
patent: 5360820 (1994-11-01), Hagan et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5538982 (1996-07-01), Hagan et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5576317 (1996-11-01), Gonsalves et al.
patent: 5696123 (1997-12-01), Dollinger et al.
patent: 5698538 (1997-12-01), Amparo et al.
patent: 5708006 (1998-01-01), Dollinger et al.
patent: 5710169 (1998-01-01), Russell et al.
patent: 5716942 (1998-02-01), Dorn et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5814636 (1998-09-01), Katano et al.
patent: 5859015 (1999-01-01), Graham et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5935951 (1999-08-01), Ofner et al.
patent: 5952315 (1999-09-01), Baker et al.
patent: 5977104 (1999-11-01), Baker et al.
patent: 5985881 (1999-11-01), Dollinger et al.
patent: 5998444 (1999-12-01), Russell et al.
patent: 6037352 (2000-03-01), Lowe et al.
patent: 6057323 (2000-05-01), Zhang et al.
patent: 6090807 (2000-07-01), Hellendahl et al.
patent: 6114315 (2000-09-01), Baker et al.
patent: 6117855 (2000-09-01), Carlson et al.
patent: 6147083 (2000-11-01), Russell et al.
patent: 6191135 (2001-02-01), Dollinger et al.
patent: 6191139 (2001-02-01), Hagan et al.
patent: 6197772 (2001-03-01), Janssens et al.
patent: 6235732 (2001-05-01), Dollinger et al.
patent: 6288068 (2001-09-01), Lowe et al.
patent: 6319953 (2001-11-01), Carlson et al.
patent: RE37886 (2002-10-01), Janssens et al.
patent: 6521621 (2003-02-01), Janssens et al.
patent: 6642240 (2003-11-01), Alvaro et al.
patent: 2002/0103205 (2002-08-01), Lowe et al.
patent: 2519400 (1978-04-01), None
patent: 287734 (1987-10-01), None
patent: 293532 (1987-10-01), None
patent: 0532456 (1993-03-01), None
patent: 0655442 (1995-05-01), None
patent: 718287 (1995-12-01), None
patent: 0721941 (1996-07-01), None
patent: 1-326 632 (2003-07-01), None
patent: 1508062 (1975-04-01), None
patent: 57/118587 (1982-07-01), None
patent: WO 92/16111 (1992-10-01), None
patent: WO 95/00498 (1995-01-01), None
patent: WO 95/25443 (1995-09-01), None
patent: WO 96/02503 (1996-02-01), None
patent: WO 96/03378 (1996-02-01), None
patent: WO 96/10562 (1996-04-01), None
patent: WO 96/14844 (1996-05-01), None
patent: WO 96/20173 (1996-07-01), None
patent: WO 97/16440 (1997-05-01), None
patent: WO 97/24324 (1997-07-01), None
patent: WO 97/32865 (1997-09-01), None
patent: WO 97/36592 (1997-10-01), None
patent: WO 97/36593 (1997-10-01), None
patent: WO 97/36888 (1997-10-01), None
patent: WO 97/36889 (1997-10-01), None
patent: WO 98/01133 (1998-01-01), None
patent: WO 98/20001 (1998-05-01), None
patent: WO 98/57954 (1998-12-01), None
patent: WO 99/09985 (1999-03-01), None
patent: WO 99/26921 (1999-06-01), None
patent: WO 99/37304 (1999-07-01), None
patent: WO 01/25219 (2001-04-01), None
patent: WO 02/00631 (2002-01-01), None
patent: WO 02/32867 (2002-04-01), None
patent: WO 02/032867 (2002-04-01), None
patent: WO 02/055518 (2002-07-01), None
patent: WO 02/057233 (2002-07-01), None
patent: WO 04/033428 (2004-04-01), None
patent: WO-04 091624 (2004-10-01), None
Challet, E., et al. Neuropharmacology 40(3):408-415 (2001).
Davis, David T., “Synthesis A. Biological Activity of a Series of Piperazin-2, 3-Biones,” Journal of Antibiotics, vol. XLII, No. 3, 1989, pp. 367-373.
Megens, A., et al. J. Pharmacology and Experimental Therapeutics 302(2):696-709 (2002).
Pacher, P., et al. “Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants.” Current Medicinal Chemistry, 5, pp. 381-390, 1998.
Romerio, et al. Clinical Pharmacology and Therapeutics 66(5):522-527 (1999).
Rupniak et al. “Differential inhibition of foot tapping and chromodacyorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK, receptor antagonists.” European Journal of Pharmacology 265:179-183 (1994).
Giardina G.A.M., et al; Recent advances in neurokinin-3 receptor antagonists.: Expert Opinion On-Therapeutic Patients; 2000. 10(6); 939-960; Ashley Publications; GB.
Acute Stress Disorder; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; pp. 469-472; American Psychiatric Association; Washington, DC, USA.
Anxiety Disorders; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; 429-30; American Psychiatric Association; Washington, DC, USA.
Argyropoulos, et al.; Exp. Opin. Invest. Drugs; 2000; 9/6; 1871-1876.
Ballard, et al.; European Journal of Pharmacology; 2001; 412; 266-284.
Kramer et al.; Science; 1998; 281; 1640-1646.
Scrima, et al.; Biol Psychiatry; 1989; 26; 331-343.
Sleep disorders; Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2000; Fourth Edition; 597-661; American Psychiatric Association; Washington, DC, USA.
Alvaro Giuseppe
Di Fabio Romano
Spada Simone
Tranquillini Maria Elvira
Glaxo Group Limited
Morgan Lorie Ann
Tucker Zachary C.
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