Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-02-07
2008-09-16
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S215000
Reexamination Certificate
active
07425567
ABSTRACT:
A piperidine derivative of formula (I)(wherein all symbols are as described in the specification.) and an intermediate for the preparation thereof. The compound of formula (I) has phosphodiesterase 4 inhibitory activity, and it is useful for the prevention and/or treatment of inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, ocular diseases, osteoporosis, bone fracture, osteoarthritis, obesity, bulimia, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia, acquired immunodeficiency deficiency syndrome (AIDS), shock, systemically inflammatory responsive diseases (SIRS), etc.
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patent: WO 02/14280 (2002-02-01), None
Seddon “Pseudopolymorph . . . ” Crystal growth and design, 496) 1087 (2004).
Evans “An introduction to crystal chemistry” Cambridge press, p. 393-396 (1964).
Braga et al. “Making crystals . . . ” Chem. Commun. p. 3635-3645 (2005).
Down et al. “Clinical pharmacology of . . . ” Clin. Pharmcokineti. v.45(3), p. 217-233 (2006).
Hamano Masaya
Nishita Yoshitaka
Ochiai Hiroshi
Ohtani Tazumi
Chang Celia
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
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