Piperidine derivative and process for preparing the same

Details Piperidine derivative and process for preparing the same Piperidine derivative and process for preparing the same

1998-04-02

1999-09-07

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21122

Patent

active

059489146

ABSTRACT:
A piperidine derivative, which can be used as an intermediate for pharmaceuticals such as paroxetine useful as antidepressants, represented by the general formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, benzyloxycarbonyl group or tert-butoxycarbonyl group; R.sup.2 is hydroxymethyl group, an alkylsulfonyloxymethyl group having an alkyl moiety of 1 to 2 carbon atoms, phenylsulfonyloxymethyl group which may have methyl group at the 4-position, (3,4-methylenedioxyphenyl)oxymethyl group, carboxyl group or --CO.sub.2 R.sup.7 group in which R.sup.7 is an alkyl group having 1 to 5 carbon atoms, and Z is methylene group or carbonyl group.

REFERENCES:
patent: 3912743 (1975-10-01), Christensen et al.
patent: 4007196 (1977-02-01), Christensen et al.
patent: 4721723 (1988-01-01), Barnes et al.
patent: 4861893 (1989-08-01), Borrett
patent: 4902801 (1990-02-01), Faruk et al.
patent: 5039803 (1991-08-01), Smith et al.
patent: 5258517 (1993-11-01), Zepp et al.
Life. Sci., 47(14), 1213-1219 (1990).
J. Labelled Compd. Radiopharm., 33(8), 777-781 (1993).
Chemical Abstracts, 114:6300s (1991).
J. Org. Chem., 22, 261-265 (1957).
Koblsch, C. F., JACS, 65, 2459-2460 (1943).
J. Org. Chem., 46, 5064-5074 (1981).
Ther. Drug Monit., 16(4), 400-406 (1994).
Buxton, P. Christopher et al., "Solid-state forms of paroxetine hydrochloride," International Journal of Pharmaceutics, 42, (1988) 135-143.
Buxton, P. Christopher et al., "Infrared Spectroscopic Studies on the Solid State Forms of Paroxetine Hydrochloride," Analytical Proceedings 25, 305-306 (1988).
121:230462y "Optically active amines and their manufacture, intermediates, and uses," Chemical Abstracts, vol. 121, 1994.
Montzka, Thomas A. et al., "Substituted Tartranilic Acids. A New Series of Resolving Acids," Journal of Organic Chemistry, 33, 3393-3395 (1986).
Engelstoft M. et al., "Synthesis and 5-HT Modulating Activity of Stereoisomers of 3-Phenoxymethyl-4-Phenylpiperidines", Acta Chemica Scandinavica, vol. 50, No. 2, Feb. 1996, pp. 164-169.
Mathis, C.A.. et al., "Binding Potency of Paroxetine Analogues for the 5-Hydroxytryptamine Uptake Complex", J. Pharm. Pharmacol., vol. 44, No. 10, Oct. 1992, pp. 801-805.
Herdeis, C. et al., Synthesis of Homochiral Piperidine Derivatives from S-Glutamic Acid. Stereoselective 1,4-Addition of Organocuprates to a delta-3-piperidine-2-one. A Paroxetine Analogue., Tetrahedron: Asymetry, vol. 7, No. 3, Mar. 1996, pp. 867-884.
Willocks, K. et al., "The Synthesis of 14C-3S,4R-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenyoxymethyl)piperidin e Hydrochloride (BRL 29060A), and Mechanistic Studies Using Carbon-13 Labelling", Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, No. 8, 1993, pp. 783-794.
Spanish Patent Application No. 9600818 Filed Apr. 10, 1996.
Spanish Patent Application No. 9600369 Filed Feb. 16, 1996.

Affiliated with

Also associated with

Rating

Piperidine derivative and process for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine derivative and process for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine derivative and process for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1805578