Piperidine derivative and pharmaceutical composition containing

Details Piperidine derivative and pharmaceutical composition containing Piperidine derivative and pharmaceutical composition containing

1990-10-09

1992-06-02

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514265, 514312, 514314, 544267, 544271, 544353, 544354, 544355, 546121, 546156, 546157, 546168, 546172, A61K 3147, A61K 3152, A61K 31495, C07D47304

Patent

active

051186896

ABSTRACT:
A new piperidine compound is pharmacologically effective for treatment of arrythmia and has the formula: ##STR1## in which R.sup.1 is lower alkyl or tolyl; R.sup.2 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl or cycloalkylalkyl; X is --CO--, --CH.sub.2 -- or --CHOH--; the sum of g plus h equals the integer 3 or 4 with g and h being 1, 2 or 3; A is substituted or unsubstituted alkylene, alkenylene, --(CH.sub.2).sub.k --S--, wherein k is an integer of 2 to 5, or --(CH.sub.2).sub.p CO--, wherein p is an integer of 1 to 4; and B is a compound having at least one heterocyclic ring containing a nitrogen atom.

REFERENCES:
Wong et al., C.A. 107:32609z (1987).

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