Piperidine derivative and pharmaceutical composition containing

Details Piperidine derivative and pharmaceutical composition containing Piperidine derivative and pharmaceutical composition containing

1987-02-18

1989-10-24

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514343, 544130, 544238, 544256, 544282, 544312, 544333, 544349, 544405, 546112, 546174, 546200, 546201, 546207, 546209, 546210, 546212, 546214, 546225, 546230, 546232, 546235, 546278, 546281, 546194, A61K 3140, A61K 3144, A61K 31445, A61K 31495

Patent

active

048762628

ABSTRACT:
A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH2-- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH2)n--, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,

REFERENCES:
patent: 2682544 (1954-06-01), Archer
patent: 4117151 (1978-09-01), Descamps et al.
patent: 4244963 (1981-01-01), Grier et al.

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