Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-08-05
1993-03-02
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 514327, 546194, 546213, 546242, A61K 31445
Patent
active
051909596
ABSTRACT:
A piperidine derivative having the formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C.sub.1-5 alkyl group or a C.sub.1-5 alkoxyl group, (ii) a C.sub.3-7 cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R.sup.3 is (i) hydrogen atom, (ii) a halogen atom, (iii) a C.sub.1-4 alkyl group or (iv) a C.sub.1-4 alkoxyl group, R.sup.4 is (i) hydrogen atom or (ii) a C.sub.1-4 alkyl group. R.sup.5 is (i) a not-substituted C.sub.1-5 alkyl group or a C.sub.1-5 alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C.sub.1-6 alkylene group, (ii) a C.sub.2-6 alkenylene group or (iii) a C.sub.3-6 alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.
REFERENCES:
patent: 4942238 (1990-07-01), Rytz et al.
Hori Toshimitsu
Koyama Toshihiro
Murai Satoshi
Nakamura Tsutomu
Ogawa Masaru
Davis Zinna N.
Kaken Pharmaceutical Co. Ltd.
Rotman Alan L.
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