Piperidine compounds for use in the treatment of bacterial...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S370000, C544S408000, C546S244000, C548S205000, C548S562000

Reexamination Certificate

active

08071605

ABSTRACT:
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

REFERENCES:
patent: 2005026149 (2005-03-01), None
patent: 2006087543 (2006-08-01), None
patent: 2008020222 (2008-02-01), None
patent: 2008152418 (2008-12-01), None
Eakin Novel DNA Gyrase Inhibitors: Fragment-Based NMR Screening to Antibacterial Agents. Presentation at 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, DC, Oct. 25, 2008).
Green et al. “Novel DNA Gyrase Inhibitors: Structure Guided Discovery and Optimization of Pyrrolamides” Poster at 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, DC, Oct. 25, 2008) F1-2025.
Hull et al. “Novel DNA Gyrase Inhibitors: The Effect of Pyrrolamide Variations at Site 1 and Site 2 Upon Potency” Poster at 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, DC, Oct. 25, 2008) F1-2027.
Illingworth et al. “Novel DNA Gyrase Inhibitors: Microbiological Characterization and in Vivo Efficacy of Pyrrolamides” Poster at 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, DC, Oct. 25, 2008) F1-2028.
Sherer et al. “Novel DNA Gyrase Inhibitors: The Effects of Pyrrolamide Linker Variations Upon Potency” Poster at 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, DC, Oct. 25, 2008) F1-2026.
Sherer et al. “Novel DNA Gyrase Inhibitors: Improvement of Pyrrolamide Antibacterial Activity by 3-Fluoropiperidine Linkers” Poster at 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco, CA, Sep. 15, 2009) F1-1977.
Uria-Nickelsen et al. “Novel DNA Gyrase Inhibitors: Investigation of the Mechanism of Action of Pyrrolamides” Poster at 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco, CA, Sep. 15, 2009) F1-2029.
Uria-Nickelsen et al. “Novel DNA Gyrase Inhibitors: Microbiological Characterization and in Vivo Efficacy of 3-Fluoropiperidine Pyrrolamides” Poster at 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco, CA, Sep. 15, 2009) F1-1978.

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