Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-13
2007-03-13
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S220000
Reexamination Certificate
active
10486925
ABSTRACT:
Novel bisulphate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes in the rat which limited to marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of stress-related affective disorders such as anxiety, depression, migraine and sleep apnea. The preferred bisulphate salts are 3(3,5-dimethoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione bisulphate and, especially, 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione bisulphate.
REFERENCES:
patent: 4835151 (1989-05-01), Gittos
Hasegawa et al., The Tryptophan Hydroxylase Activation Inhibitor, AGN-2979, Decreases Regional 5-HT Synthesis in the Rat Brain Measured with α-[14C]Methyl-L-Tryptophan: An Autoradiographic Study, Brain Research Bulletin, 67:248-255 (2005).
Bacon & Thomas PLLC
Balls R. James
Chang Celia
Prestwick Pharmaceuticals, Inc.
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