Piperid-4-yl ureas and thio ureas used as anti-depressant agents

Details Piperid-4-yl ureas and thio ureas used as anti-depressant agents Piperid-4-yl ureas and thio ureas used as anti-depressant agents

1982-04-07

1984-01-17

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546169, 546170, 424263, 546171, 546183, 546224, 546112, 546123, 546205, 546124, 546174, 546206, 546270, 544233, 546305, 544237, 544238, 546306, 546203, 546204, 546285, 546196, 546214, 546202, 546212, 546197, 546143, 546145, 546146, 546147, 546148, 546193, 546194, 546256, 546261, 546262, 546263, 546264, 546201, 546200, 546153, 546159, 546162, 546168, A61K 31445, C07D21156

Patent

active

044263872

ABSTRACT:
The invention concerns compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q is O,S,--CR.sup.7 .dbd.CR.sup.8 --, --N.dbd.CR.sup.8 -- and --N.dbd.N--; R.sup.4, R.sup.5 and R.sup.6, and R.sup.7 and R.sup.8 when present, each represent hydrogen or defined substituents and additionally either R.sup.4 and R.sup.5 when adjacent or R.sup.6 and R.sup.8 when adjacent, together with the carbon atoms to which they are attached also represent a fused five or six membered carbocyclic or heterocyclic ring optionally carrying one or more defined substituents; R is an optionally substituted aryl or heteroaryl radical or a cycloalkyl radical containing 5 to 7 carbon atoms; R.sup.1, R.sup.2, R.sup.3 and R.sup.9 are each hydrogen or a lower alkyl group; n is 0 or 1; X is .dbd.O, .dbd.S or .dbd.NH; Y is --O-- or a direct bond and Z is --CO-- or --CH.sub.2 -- with the proviso that when Ar is unsubstituted phenyl and R.sup.9 is hydrogen then Y is --O--. The compounds of formula I exhibit psychotropic activity and are useful as antidepressants. Processes for preparing the compounds and pharmaceutical compositions containing them are disclosed.

REFERENCES:
Katsuo et al., Chem. Abs. 88-22640c.

Affiliated with

Also associated with

Rating

Piperid-4-yl ureas and thio ureas used as anti-depressant agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperid-4-yl ureas and thio ureas used as anti-depressant agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperid-4-yl ureas and thio ureas used as anti-depressant agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-700513