Piperazinylalkylcarboxylic acid adamantylamides

Details Piperazinylalkylcarboxylic acid adamantylamides Piperazinylalkylcarboxylic acid adamantylamides

1989-09-27

1990-05-01

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544357, 544360, 544380, C07D40304, C07D29510, C07D29512

Patent

active

049219588

ABSTRACT:
The compounds of the formula: ##STR1## wherein Ad is 1-adamantyl, 2-adamantyl or 3-noradamantyl; n is 1,2,3,4 or 5; R.sup.1 hydrogen, alkyl, phenyl, benzyl, or substituted phenyl or benzyl in which the substituent is alkyl, alkoxy, halo, cyano, nitro or trifluoromethyl; R.sup.2 is phenyl, benzyl or substituted phenyl or benzyl in which the substituent is alkyl, alkoxy, halo, nitro, cyano or perhalomethyl, 2-, 3-, or 4-pyridinyl, 2-, 4- or 5-pyrimidinyl or 2- or 3-pyrazinyl; R.sup.3 and R.sup.4 are, independently, hydrogen, methyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, are useful anxiolytic/antidepressant agents, with elements of antipsychotic activity.

REFERENCES:
patent: 4202898 (1980-05-01), Depoortere
Derwent Abstract 85000957/01-German Patent No. 3321-969 (1984).
Derwent Abstract 87-049798/07-U.S. Pat. No. 4,640,921 (1987).
Barone, et al., Drug Clin. Pharm., 20, 770, 1986.

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