Piperazinones, their production and use

Details Piperazinones, their production and use Piperazinones, their production and use

1998-09-01

2000-02-01

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 544367, 544384, A61K 31495, C07D24108

Patent

active

06020334&

ABSTRACT:
The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention perform platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity. Compounds of this invention are piperazinones of the formula ##STR1##

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patent: 5545658 (1996-08-01), Alig et al.
patent: 5550131 (1996-08-01), Sugihara et al.
Takenaka et al., Chemical Abstracts, vol. 120, No. 31211v, p. 903, col. 1, Jan. 17, 1994.
Takenaka et al., Chemistry Express, vol. 8, No. 9., "Takenaka: Preparation of optically active N,N.sup.1 -ethylene-bridged dipetides as units of pseudopeptides"., pp. 697-700, 1993.
Ruoslahtl et al., Science, vol. 238, pp. 491-496 (1987).
Pierschbacher et al., Journal of Biological Chemical vol. 262, No. 35, pp. 17294-17297, (1987).
Receptor data for Biological Experiments by Doods and Van Meel, pp. 112-117 (1991).

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