Piperaziniocephalosporins

Details Piperaziniocephalosporins Piperaziniocephalosporins

1990-08-23

1992-09-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514202, 514206, 540221, 540222, C07D50138, A61K 31545

Patent

active

051439107

ABSTRACT:
Antibacterial hydroxyarylpiperazinocephalosporins of the formula: ##STR1## wherein R.sup.1 is amino or acylamino; R.sup.2 is H or methoxy; R.sup.3 is alkyl; R.sup.4 is --(P--C--Q).sub.n --, where P and Q each are H, alkyl or OH, or P and Q combine to form oxo, and n is 0 or 4; R.sup.5 is substituted or unsubstituted hydroxyaryl; R.sup.6 has a negative charge and is COO, or an anion in combination with an optionally protected carboxy; and X is O, S or S.fwdarw.O; an antibacterial preparation containing the same; a method for killing bacteria and preventing or treating bacterial infection by using the same; and syntheses of the cephalosporins are provided.

REFERENCES:
patent: 4782155 (1988-11-01), Nakagawa et al.
patent: 4785090 (1988-11-01), Tsuruoka et al.
patent: 4880795 (1989-11-01), Angerbauer et al.

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