Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-05-17
2011-05-17
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S253110, C514S253120, C544S360000, C544S364000
Reexamination Certificate
active
07943622
ABSTRACT:
Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
REFERENCES:
patent: 5880128 (1999-03-01), Doll et al.
patent: 6372747 (2002-04-01), Taveras et al.
patent: 6878700 (2005-04-01), Link et al.
patent: 2003/0073681 (2003-04-01), Hauske et al.
patent: 2004/0180880 (2004-09-01), Lauffer et al.
patent: WO 95/00497 (1995-01-01), None
patent: WO 96/31478 (1996-10-01), None
patent: WO 96/31501 (1996-10-01), None
patent: WO 97/10219 (1997-03-01), None
patent: WO 98/20001 (1998-05-01), None
patent: WO 99/18095 (1999-04-01), None
patent: WO 03/044014 (2003-05-01), None
patent: WO 2004/014370 (2004-02-01), None
patent: WO 2004/071390 (2004-08-01), None
patent: WO 2004/087653 (2004-10-01), None
patent: WO 2005/044797 (2005-05-01), None
patent: WO 2005/080386 (2005-09-01), None
patent: WO 2006/014012 (2006-02-01), None
patent: WO 2006/129199 (2006-12-01), None
Huang et al., “Guiding Farnesyltransferase Inhibitors from an ECLiPS Library to the Catalytic Zinc,” Bioorganic & Medicinal Chemistry Letters, 16(3):507-511 (2006).
Brockunier L. et al., “Substituted Piperazines as Novel Dipeptidyl Peptidase IV Inhibitors,” Bioorganic and Medicinal Chemistry Letters, 14(18):4763-4766 (2004).
Gundish, D., “Nicotinic Acetylcholine Receptor Ligands as Potential therapeutics,” Expert Opinion on Therapeutic Patents, 15(9):1221-1239 (2005).
Chen J. et al., “N, N-Disubstituted Piperazines: Synthesis and Affinities at alpha 4 beta 2 and alpha 7 neuronal nicotinic acetylcholine receptors,” Bioorganic and Medicinal Chemistry Letters, 13(1):97-100 (2003).
Lin, N.H. et al., “Recent Developments in Neuronal Nicotinic Acetylcholine Receptor Modulators,” Expert Opinion on Therapeutic Patents, 8(8):991-1015 (1998).
Clark Roger B.
Elbaum Daniel
Cornerstone Therapeutics, Inc.
Fix Amy H.
Sackey Ebenezer
Wilson James O
Womble Carlyle Sandridge & Rice PLLC
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