Piperazines and homopiperazines

Details Piperazines and homopiperazines Piperazines and homopiperazines

1989-02-15

1990-10-02

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

544120, 544360, 544363, 544373, 544374, 544383, C07D24308, C07D24150, C07D41306, C07D40508

Patent

active

049608835

ABSTRACT:
A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group,
and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

REFERENCES:
patent: 4051125 (1977-09-01), Tanaka et al.

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