Piperazinedione compounds

Details Piperazinedione compounds Piperazinedione compounds

2007-10-30

2007-10-30

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S253120, C514S253010, C514S255020, C514S249000, C544S360000, C544S364000, C544S349000, C544S350000, C544S385000

Reexamination Certificate

active

10689865

ABSTRACT:
This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula:In the above formula, each ofand, independently, is a single bond or a double bond; A is H or CH(RaRb) whenis a single bond, or C(RaRb) whenis a double bond; Z is CH(RcRd) whenis a single bond, or C(RcRd) whenis a double bond; each of R1and R2, independently, is H, C(O)Re, C(O)ORe, C(O)NReRf, or SO2Re; and each of Ra, Rb, Rc, Rd, Re, and Rf, independently, is H, C1-C6alkyl, aryl, heteroaryl, C3-C8cycloalkyl, or C3-C8heterocycloalkyl; or Raand Rbtaken together are C3-C8cycloalkyl, C3-C8heterocycloalkyl, aryl, or heteroaryl; or R1and Raor R1and Rbtaken together are C3-C8cycloalkyl, C3-C8heterocycloalkyl, aryl, or heteroaryl; provided that one of Rcand Rdis aryl or heteroaryl.

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