Piperazine substituted pyrimidine derivatives and physiologicall

Details Piperazine substituted pyrimidine derivatives and physiologicall Piperazine substituted pyrimidine derivatives and physiologicall

1990-02-20

1992-08-11

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544326, 544327, C07D40304

Patent

active

051380587

ABSTRACT:
Pyrimidine derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, the salts thereof, and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable as a tool in a pharmacological screening model for aldose reductase inhibitors.

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patent: 4885296 (1989-12-01), Mahoury et al.
patent: 4975530 (1990-12-01), Tzikas et al.
Journal of the Chemical Society, Chemical Communications No. 24, 1976, pp. 1060, 1061, J. H. Forsberg et al.
Journal of Organic Chemistry, vol. 52, 1987, pp. 1017-1021, J. H. Forsberg et al.

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