Piperazine-substituted aryl and aralkyl carboxylic acids useful

Details Piperazine-substituted aryl and aralkyl carboxylic acids useful Piperazine-substituted aryl and aralkyl carboxylic acids useful

1984-10-01

1986-10-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544393, 544395, 544398, 544399, 544400, 514255, C07D24104, A61K 31495

Patent

active

046160868

ABSTRACT:
The present invention is concerned with new carboxylic acid derivatives, with processes for the preparation thereof and with pharmaceutical compositions for lipid depression and thrombocyte aggregation, containing them, and to methods for treating infirmaties caused by excess lipids or thrombocyte aggregation.
The new carboxylic acid derivatives according to the present invention are compounds of the general formula: ##STR1## wherein A is a valency bond or a lower alkylene chain, B is a valency bond or a saturated or unsaturated lower alkylene chain, R is hydrogen, an alkyl group which can be substituted by hydroxyl, carboxyl, sulphonic acid or optionally substituted phenoxy group, or R is an aralkyl radical, the aryl moiety of which can be substituted and the alkyl moiety of which is optionally unsaturated and can contain up to 4 carbon atoms, or R is a phenacyl radical, the phenyl moiety optionally substituted, or R is an acyl radical derived from aliphatic, araliphatic or aromatic carboxylic or sulphonic acid, or R is an aryl radical optionally substituted with the proviso that when A is a valency bond, R cannot be hydrogen, methyl, ethyl, hydroxyethyl, benzyl or phenyl, and the physiologically acceptable salts, esters and amides thereof.

REFERENCES:
patent: 3448192 (1969-06-01), Mauwernay
patent: 3641040 (1972-02-01), Carney
patent: 3910916 (1975-10-01), Protiva et al.
Medicinal Chemistry, Alfred Burger, p. 42, col. 2, last paragraph.
Hansl, N., Chem. Abstract, vol. 80, 1974, p. 353, 82431e, Alkyl m-(2-aminoethyl)benzoates.
Cazin et al, Chem. Abstract, vol. 94, 1981, p. 25, 57963m, In Vitro Study of the Inhibitory Effect of Various .beta.-Aminoketones on Platelet Aggregation.
Cazin, Publ., Acta Therapeutica 6 (1980).

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