Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-11-15
1991-05-14
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540314, 540316, 544357, 544358, C07D50122, A61K 31545
Patent
active
050157361
ABSTRACT:
A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chloride or a derivative thereof.
The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II ##STR2## where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenylacetamido)-cephalosporanic acid.
REFERENCES:
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patent: 4110327 (1978-08-01), Saikawa et al.
patent: 4110328 (1978-08-01), Diamond
patent: 4200744 (1989-04-01), Saikawa et al.
patent: 4436921 (1984-03-01), Hori et al.
Cabre Castellvi Juan
Diago Meseguer Jose
Esteve Bianchini Asuncion
Lenhardt Padro Carlos E.
Sans Pitarch Esteve
GEMA, S.A.
Honor Robert S.
McGovern Thomas O.
Rizzo Nicholas S.
Sharkin Gerald D.
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