Piperazine derivatives with anticholinergic and/or antihistamini

Details Piperazine derivatives with anticholinergic and/or antihistamini Piperazine derivatives with anticholinergic and/or antihistamini

1982-09-27

1984-07-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602433, 4242484, 544121, 544360, A61K 31495, C07D40100, C07D41300

Patent

active

044579314

ABSTRACT:
Compounds of formula I ##STR1## are described in which R is an aryl, substituted aryl, aralkyl or heterocyclic radical; R.sup.1 is hydrogen or alkyl of 1-4 carbon atoms; A is a saturated, aliphatic hydrocarbon chain, which is linear or branched; R.sup.2 and R.sup.3 are the same or different and are hydrogen, linear or branched alkyl, aryl, substituted aryl or together with the nitrogen atom to which they are connected and together with y form a ring wherein y is a methylene group or a heteroatom, which is selected from the group consisting of nitrogen, oxygen and sulfur; R.sup.4 is hydrogen or linear or branched alkyl; X is halogen or an organic or inorganic anion; n is 0; 1; 2; 3 or in the case of a bifunctional acid, n is equal to 0.5; 1.5; 2.5 and their enantiomers and diestereoisomers. Several methods of preparation of the novel compounds are described.

REFERENCES:
Bernstein (Squibb), Chem. Abst., vol. 73, (1970), p. 379, 77294p, Adamantane Derivatives, Having Depressant and Antihistaminic Activity.
Frech Squibb, Chem Abst., vol. 74, (1971), p. 603, 141906q, Adamantyl Dibenzoxazepines as Antihistaminic, Antiparkinsonism, Tranquilizing, and Sedative Agents.

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