Piperazine derivatives useful as CCR5 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S252120, C514S252130, C514S252190, C514S253010, C514S253100, C514S253110

Reexamination Certificate

active

07384944

ABSTRACT:
The use of CCR5 antagonists of the formulaor a pharmaceutically acceptable salt thereof, whereinR is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl;R1is hydrogen or alkyl;R2is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl;R3is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl;R4, R5and R7are hydrogen or alkyl;R6is hydrogen, alkyl or alkenyl;for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

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