Piperazine derivatives and methods of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S227500, C514S237500, C544S059000, C544S158000, C544S384000

Reexamination Certificate

active

07393852

ABSTRACT:
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

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Bailey, et al., Tetrahedron Letters,Piperzine-2,3,5-triones in the synthesis of constrained peptides, 40, 7557-7560 (1999).
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