Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

1994-04-22

1995-07-04

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 544295, 544363, 544364, 544372, 544373, 544376, 544377, 544392, A61K 31495, C07D40300, C07D40100, C07D40500

Patent

active

054300339

ABSTRACT:
Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents, particularly 5-HT.sub.1A antagonists and may be used, for example, as anxiolytics. In the formula R is hydrogen or one or two lower alkyl groups, R.sup.1 is a mono of bicyclic aryl or heteroaryl radical, R.sup.2 is aryl and A is a C.sub.2-5 alkylene chain optionally substituted by lower alkyl.

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