Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-11-01
1981-05-05
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
542470, 544391, 544397, A61K 31495, C07D29502
Patent
active
042658942
ABSTRACT:
Piperazine derivatives of the general formula ##STR1## wherein R.sub.1 -R.sub.9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH.sub.2).sub.m (in which m is 1, 2, 3 or 4) or a group --CH.sub.2 --CH.dbd.CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described.
The compounds exhibit a strong specific dopaminergic activity.
Also described are methods for their preparation and use as therapeutic agents in the form of therapeutic compositions.
Adams Bruce L.
Burns Robert E.
Daus Donald G.
Gist Brocades N.V.
Lobato Emmanuel J.
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