Piperazine Derivatives

Details Piperazine Derivatives Piperazine Derivatives

1994-11-14

1996-07-30

Tsang, Cecila

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544360, 544368, 544373, 544393, 544394, 544359, A61K 31495, C07D24104, C07D40300

Patent

active

055413269

ABSTRACT:
Piperazine derivatives of formula: ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, n is 1 or 2; R and R.sup.5 are hydrogen or lower alkyl, R.sup.1 is substituted or unsubstituted aryl or a heteroaromatic radical; R.sup.3 is substituted or unsubstituted aryl or substituted or unsubstituted arylalkyl; R.sup.9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or substituted or unsubstituted arylalkyl with the proviso that when R.sup.9 is hydrogen, alkyl, or arylalkyl, R.sup.5 is other than a tertiary alkyl group. The compounds of this invention are useful 5-HT.sub.1A antagonists for the treatment of CNS disorders such as anxiety.

REFERENCES:
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Morren et al., Inc. Chim. Belg., 1963, 28, 123-34 (w/translation).
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Bouchara et al., Chem. Abst. 81:3776r (1974).
Chem. Abst. 110:57687y (1969) Vejdelek et al. Czech. CS 243,594-15 Nov. 1987.
Chem. Abst. 89:146938w J78 59,675 (29/05/78) (Yoshitomi Pharm Ind, Ltd.).
Derwent Abst. 48671A/27 (J5 3059-675,29/05/78) (same as Chem Abst. 89:146938w).

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