Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1995-04-04
1997-10-28
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544371, 544364, 544121, 544368, 544392, 544394, 544372, 544393, 544359, 544373, 544379, 544360, 544370, 544114, C07D41300
Patent
active
056819544
ABSTRACT:
A compound represented by formula (I): ##STR1## wherein Q represents an aryl group, a heterocyclic group, a diarylmethyl group, an aralkyl group composed of an aryl group and an alkylene group, an alkyl group or a cycloalkyl group, in which the aryl group, heterocyclic group, and the aryl moiety of the diarylmethyl group and aralkyl group may be substituted with one or more substituents; R represents a bicyclic, substituted, nitrogen-containing heterocyclic group or a substituted phenyl group, in which the nitrogen-containing heterocyclic group is composed of a 5-membered, substituted, aromatic or saturated ring containing one or two nitrogen atoms and a 6-membered ring; and Z represents an alkylene group, an alkenylene group, an alkylene group, a carbonyl group, an alkylene group containing a carbonyl group or an oxalyl group, or a salt thereof. The compound has calmodulin inhibitory activity and is useful as a treating agent for diseases in the circulatory organs or in the cerebral region which are caused by excessive activation of calmodulin.
REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 4179505 (1979-12-01), Raeymaekers et al.
patent: 4302589 (1981-11-01), Faushawe
patent: 4426383 (1984-01-01), Sugimoto et al.
patent: 4954503 (1990-09-01), Strupczewski et al.
patent: 4988809 (1991-01-01), Seidel et al.
patent: 5182280 (1993-01-01), Cuberes-Altisent et al.
Ando, deceased Masahiro
Hasegawa Atsushi
Kubota Hideki
Yamaguchi Hitoshi
Yamamoto Kenjiro
Daiichi Pharmaceutical Co. Ltd.
McKane Joseph
Myers, Jr. Richard S.
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