Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-19
1994-11-29
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540598, 544360, 544364, 544372, 544362, 544375, 544392, 514210, 514255, 5142358, A61K 31395, A61K 31495, C07D40306, C07D40314
Patent
active
053691032
ABSTRACT:
##STR1## where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is hydrogen or lower alkyl, R.sup.1 is a mono or bicyclic aryl or a heteroaryl radical, R.sup.2 is an aryl radical, a heteroaryl radical, or an aryl-or heteroaryl-lower alkyl radical, R.sup.3 is hydrogen, lower alkyl or aryl and R.sup.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkyl(lower)alkyl, aryl, or aryl(lower)alkyl or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring which may contain a further hetero atom and the dotted line represents a single or double bond, the hydrogen atoms shown in brackets being present when the dotted line represents a single bond and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents which may be used, for example, for the treatment of CNS disorders such as anxiety.
REFERENCES:
patent: 4921958 (1990-05-01), Abou-Gharbia et al.
patent: 4988814 (1991-01-01), Abou-Gharbia et al.
patent: 5169845 (1992-12-01), Cliffe et al.
March, Advanced Organic Chemistry (New York, McGraw-Hill Books, 1987) pp. 879-880.
Cliffe Ian A.
Ifill Anderson D.
White Alan C.
John Wyeth & Brother Limited
Seifert Arthur G.
Shah Mukund J.
Sripada P. K.
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