Piperazine CCR-3 receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S254010, C514S254100, C514S255030, C544S372000, C544S374000, C544S393000, C544S400000

Reexamination Certificate

active

06906073

ABSTRACT:
The invention provides compounds of Formula (I):wherein: R1-R4, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.

REFERENCES:
patent: 6339087 (2002-01-01), Gong et al.
patent: 0 903 349 (1999-03-01), None
patent: 5-92921 (1993-04-01), None
patent: 98/27081 (1998-06-01), None
patent: WO 99/65874 (1999-12-01), None
patent: WO 00/35449 (2000-06-01), None
patent: WO 00/35451 (2000-06-01), None
patent: WO 00/35452 (2000-06-01), None
patent: WO 00/35453 (2000-06-01), None
patent: WO 00/35454 (2000-06-01), None
Heath et al. J. Clin. Invest. vol. 99, p. 178-184 (1997).
Owen, Pulmonary Pharmacology & Therapeutics, vol. 14, p. 193-202 (2001).

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