Pipelined digital circuit for determining the conformational...

Details Pipelined digital circuit for determining the conformational... Pipelined digital circuit for determining the conformational...

2005-11-22

2005-11-22

Brusca, John S. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Chemical analysis

C700S001000

Reexamination Certificate

active

06968275

ABSTRACT:
The present invention provides a method and apparatus to significantly accelerate the searching process based on the Monte Carlo principle and the lattice model. Specifically, the energy status of a lattice-based protein conformation is evaluated by modeling the folding process through a pipelined digital circuit using a number of state machines. The pipelined digital circuit reduces the time required for the determination of the energy status of a particular conformation and, therefore, significantly accelerates the searching speed for the lowest energy status. The present invention also permits real-time tuning of problem parameters by the experimenter.

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“Computer Organization and Design: The Hardware/Software Interface”, 2ndEdition, David A. Patterson and John L. Hennessy, 1998, p. 436.

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