Pipecolic acid-containing peptolides, their preparation and phar

Details Pipecolic acid-containing peptolides, their preparation and phar Pipecolic acid-containing peptolides, their preparation and phar

1995-05-22

1997-07-01

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, A61K 3800, C07K 512, C07K 706

Patent

active

056438699

ABSTRACT:
Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I ##STR1## wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761).
They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

REFERENCES:
patent: 3585111 (1971-06-01), Coats et al.
Br. J. Cancer (1992) 65, 11-18.
Cancer Res. vol. 51, pp. 4226-4233 (1991).
Br. J. Cancer (1988) 57, 254-258.
Br. J. Cancer (1987) 56, 55-67.

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