PIM-3 kinase as a target for type 2 diabetes mellitus

Details PIM-3 kinase as a target for type 2 diabetes mellitus PIM-3 kinase as a target for type 2 diabetes mellitus

2007-06-05

2007-06-05

Zara, Jane (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S325000, C435S091100

Reexamination Certificate

active

10348081

ABSTRACT:
The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

REFERENCES:
patent: 6143540 (2000-11-01), Kapeller
patent: 0 911 391 (1999-04-01), None
patent: WO 02/093173 (2002-11-01), None
Feldman Jonathan D. et al., KID-1, A Protein Kinase Induced By Depolarization in Brain, The Journal Of Biological Chemistry, (1998), vol. 273, No. 26, pp. 16535-16543.
Konietzko Uwe et al., Pim Kinase Expression Is Induced By LTP Stimulation And Required For The Consolidation Of Enduring LTP, The EMBO Journal, (1999), vol. 18, No. 12, pp. 3359-3369.
Nadler Samuel T. et al., The Expression Of Adipogenic Genes Is Decreased In Obesity And Diabetes Mellitus, PNAS, (2000), vol. 97, No. 21, pp. 11371-11376.
Mus Musculus, Serine Theronine Kinase pmi3, Clone MGC, Database EMBL Online, (2001), Accession No. BC017621.
Protein Kinase Gene KID-1, Database EMBL Online, (2002), Accession No. BC026639.
Serine Threonine Kinase (Protein Kinase KID-1), Database EMBL Online, (1998), Accession No. 070444.

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